Symbol
Name
ID

Ptgs2
prostaglandin-endoperoxide synthase 2
MGI:97798

Phenotype annotations related to cardiovascular system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Keratoconjunctivitis sicca

Cor pulmonale

Vasculitis

Abnormal cardiac ventricular function

Portal hypertension

Pulmonary arterial hypertension

Arrhythmia

Ventricular tachycardia

Heart block

Abnormal lymph node morphology

Lymphadenopathy

Hepatosplenomegaly

Disease(s) Associated with PTGS2

cystic fibrosis

idiopathic pulmonary fibrosis

pancreatic cancer

rheumatoid arthritis

sarcoidosis

Mouse Phenotypes

cardiovascular system phenotype

abnormal choriocapillaris morphology

abnormal induced retina neovascularization

patent ductus arteriosus

increased myocardial fiber size

increased heart weight

dilated heart left ventricle

cardiac fibrosis

decreased ventricle muscle contractility

decreased heart rate

ventricular tachycardia

abnormal response of heart to induced stress

increased systemic arterial blood pressure

increased systemic arterial diastolic blood pressure

increased systemic arterial systolic blood pressure

decreased vascular permeability

Availability

Mouse Genotype

Ptgs2^tm1.1Wls/Ptgs2^tm1.1Wls

Ptgs2^tm1Fun/Ptgs2^tm1Fun

Ptgs2^tm1Jed/Ptgs2^tm1Jed

Ptgs2^tm1Unc/Ptgs2^tm1Unc

Ptgs2^tm3Fun/Ptgs2^tm3Fun

Ptgs2^tm1Unc/Ptgs2⁺

Ptgs2^tm1Gaf/Ptgs2^tm1Gaf
A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/? (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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